Fig. 8

The KEGG prostate cancer pathway hsa05215 (A) and bladder cancer pathway hsa05219 (B) [67]. The boxes represent genes. The colors visualize log₂ fold-changes of genes differentially expressed in cell lines relative to tissue samples, with yellow standing for upregulation and blue for downregulation. Boxes representing multiple genes display the mean log₂ fold-change. The visualization of deregulation was capped at log₂ fold-changes of ± 5. Boxes in the prostate cancer pathway (A) are divided into PAC on the left and PAC metastasis, while log₂ fold-changes in the TCC cell lines are shown in the bladder cancer pathway (B). With the exception of TMPRSS2, CCND1 and BCL2, whose Ensembl identifiers (ENSCAFG00000010190, ENSCAFG00000010700 and ENSCAFG00000000068) were not recognized by the visualization tool, genes depicted in white were not considered expressed