Fig. 9
From: RNA-seq of nine canine prostate cancer cell lines reveals diverse therapeutic target signatures
A The KEGG PI3K-AKT signaling pathway (cfa04151) [67]. The boxes are divided into three parts depicting DEGs in PAC, PAC metastasis, and TCC cell lines from left to right. With the exception of BCR, IRS1, CCND1 and BCL2, whose Ensembl identifiers (ENSCAFG00000013773, ENSCAFG00000010397, ENSCAFG00000010700 and ENSCAFG00000000068) were not recognized by the visualization tool, genes depicted in white were not considered expressed. The boxes on the left summarize the number of identified genes in the growth factors (GF), RTK, cytokines and receptors, focal adhesion and the chemokine signaling pathway which are differentially expressed in each histopathological classification (See Fig. 8 for details). B Western blot analysis using antibodies against PI3Kα, PI3K-p85, and Akt. Membranes were cut prior to antibody incubation and cropped to be displayed together. C Summary of the findings in the PI3K-AKT signaling pathway