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Fig. 1 | Cancer Cell International

Fig. 1

From: 4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis

Fig. 1

4, 5-Dimethoxycanthin-6-one inhibits LSD1. A Viability of T98G, U87, and U251 cells. B Dose-dependent change in LSD1 enzyme activity. C–E. LSD1 levels in the 0, 1, 2, and 4 μM groups. F Three-dimensional binding model of the LSD1 active site 4 of 4,5-dimethoxycanthin-6-one (PDB code: 5l3e). G, H Relative LSD1 expression of sh-LSD1 and sh-NC cells. I Anti-proliferation effect of 4,5-dimethoxycanthin-6-one on sh-LSD1 and sh-NC cells. *P < 0.05 compared with the 0 μM group, #P < 0.05 compared with the sh-NC group

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Cancer Cell International

ISSN: 1475-2867

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