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Fig. 7 | Cancer Cell International

Fig. 7

From: 4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis

Fig. 7

In vivo anti-tumor effects of 4, 5-dimethoxycanthin-6-one. Tumor weight (A) and volume (B). C, D Images of animals (C) and tumors (D). E Up: HE staining, down: LSD1 positivity was detected by IHC. F Cell apoptosis was tested by the TUNEL assay. G 4, 5-Dimethoxycanthin-6-one could inhibit the AKT/mTOR and MAPK expression. H Expression levels of NLRP3, Caspase1, IL-1β, and IL-18 were measured by qRT-PCR and western blot. *P < 0.05 compared with the Control group

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Cancer Cell International

ISSN: 1475-2867

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