Fig. 6

Characteristics of m6Ascore status in TCGA-PRAD tumor mutation and subtypes. A (left) TMB values in low and high m6Ascore groups. The P value is shown in box plot. (right) Correlation analysis of m6Ascore and TMB value in PCa was performed through Spearman correlation analysis. Different dots of red, orange, and blue in the scatter diagram represent geneClusters A to C, respectively. B (left) PRAD patients were divided into low and high TMB groups based on the optimum threshold segmentation of TMB values in relation to RFS. Survival analysis of the two groups is shown in the graph. (right) PRAD patients were divided into four groups based on TMB and m6Ascore status (high (H)-TMB + H-m6Ascore; H-TMB + low (L)-m6Ascore; L-TMB + H-m6Ascore; and L-TMB + L-m6Ascore), and survival analysis was performed. C The waterfall plot of tumor somatic mutations in PRAD with low m6Ascore (left) and high m6Ascore (right). D (left) The proportion of biochemical recurrence status in the m6Ascore groups (fustat of 0: no recurrence, 1: recurrence). (right) m6Ascore with respect to different biochemical recurrence statuses. The P value is shown in box plot. E Survival analysis of different m6Ascore groups among TRAD patients with GS 8–10 (left) and pT3 (right). F Box plot of PD-L1 expression in the low and high m6Ascore groups. The P value is shown in box plot. (G) Violin plot of IPS scores in ips_ctla4_neg_pd1_neg (CTLA4 negative response and PD1 negative response) in respective m6Ascore groups. The P value is shown in violin plot