Construction of a risk prediction model using m6A RNA methylation regulators in prostate cancer: comprehensive bioinformatic analysis and histological validation

Table 4 Expression levels of m6A regulators in TCGA-PRAD data stratified by pT

Gene	pT = 2 (median)	pT = 3 (median)	pT = 4 (median)	P (pT = 2 vs. pT = 3)	P symbol^a
METTL3	27.06274	26.48476	26.30134	0.365576	ns
METTL14	11.67474	11.8227	13.97603	0.853312	ns
METTL16	15.01602	14.43229	17.49281	0.229372	ns
WTAP	62.01344	59.79612	53.04483	0.06393	ns
VIRMA	14.40579	16.51078	22.99954	0.000227	***
ZC3H13	23.14228	21.01365	22.76672	0.416107	ns
RBM15	6.749674	6.883484	8.615314	0.274807	ns
RBM15B	44.14219	46.68428	55.24486	0.0486	*
CBLL1	23.00583	21.84154	30.68415	0.360921	ns
YTHDC1	38.16906	39.80338	44.09208	0.062198	ns
YTHDC2	10.47902	10.7769	17.22446	0.439427	ns
YTHDF1	61.14875	64.5393	87.48373	0.011815	*
YTHDF2	51.36317	52.29989	68.72696	0.336839	ns
YTHDF3	41.22466	44.1152	62.55585	0.148109	ns
HNRNPC	167.5473	179.2224	204.646	0.001177	**
FMR1	13.15182	14.1732	20.4288	0.001644	**
LRPPRC	44.08828	46.08805	60.92826	0.249137	ns
HNRNPA2B1	271.8575	296.6347	344.7956	1.31E-05	***
IGFBP1	0	0	0.038231	0.100044	ns
IGFBP2	187.1589	168.3542	152.7416	0.037715	*
IGFBP3	42.2307	64.22177	83.39194	2.48E-07	***
RBMX	78.0526	86.94696	119.5574	0.000471	***
ELAVL1	40.91439	42.45284	49.47014	0.002996	**
FTO	10.76108	10.90775	13.05522	0.967256	ns
ALKBH5	121.6235	120.1459	132.7814	0.579113	ns

ISSN: 1475-2867