Construction of a risk prediction model using m6A RNA methylation regulators in prostate cancer: comprehensive bioinformatic analysis and histological validation

Table 5 Expression levels of m6A regulators in TCGA-PRAD data stratified by TP53 mutation

Gene	Wild type (median)	Mutation (median)	P value (wild vs. mut)	P symbol^a
METTL3	26.66187	28.77871	0.155657	ns
METTL14	11.7543	11.92501	0.210393	ns
METTL16	14.83022	12.4188	0.001348	**
WTAP	61.08309	59.07833	0.694618	ns
VIRMA	15.52701	18.9505	0.000697	***
ZC3H13	20.69471	24.60509	0.071727	ns
RBM15	6.887572	6.931969	0.381289	ns
RBM15B	46.10196	52.61076	0.008893	**
CBLL1	21.93925	24.83281	0.144508	ns
YTHDC1	38.77673	44.14293	0.01052	*
YTHDC2	10.51239	12.71358	0.008028	**
YTHDF1	62.76196	66.50237	0.045122	*
YTHDF2	51.76176	60.97605	0.011735	*
YTHDF3	42.92899	48.0619	0.037743	*
HNRNPC	175.4147	186.623	0.013856	*
FMR1	13.67919	15.39546	0.028109	*
LRPPRC	45.50271	55.43345	0.04845	*
HNRNPA2B1	285.6907	320.1461	0.005563	**
IGFBP1	0	0	0.328748	ns
IGFBP2	182.2817	130.7453	7.05E-05	***
IGFBP3	54.82908	76.41379	0.000933	***
RBMX	82.82156	93.84054	0.009741	**
ELAVL1	42.00761	42.3959	0.435743	ns
FTO	10.87488	9.600595	0.738732	ns
ALKBH5	119.9799	121.8514	0.551667	ns

ISSN: 1475-2867