Table 1 Association between TOP2A expression and the clinical parameters in patients with hepatocellular carcinoma in TCGA
|  | Total (N = 339) (%) | TOP2A Expression | P-value | |
|---|---|---|---|---|
High (N = 113) (%) | Low (N = 226) (%) | |||
Age (year) | Â | Â | Â | 0.00399 |
  < 65 | 208 (61.4) | 82 (72.6) | 126 (55.8) |  |
  ≥ 65 | 131 (38.6) | 31 (27.4) | 100 (44.2) |  |
Gender | Â | Â | Â | 0.108 |
 Male | 231 (68.1) | 70 (61.9) | 161 (71.2) |  |
 Female | 108 (31.9) | 43 (38.1) | 65 (28.8) |  |
Family history of cancer | Â | Â | Â | 0.148 |
 No | 196 (57.8) | 72 (63.7) | 124 (54.9) |  |
 Yes | 98 (28.9) | 25 (22.1) | 73 (32.3) |  |
 Unknown | 45 (13.3) | 16 (14.2) | 29 (12.8) |  |
TNM stage |  |  |  |  < 0.001 |
 I | 170 (50.1) | 36 (31.9) | 134 (59.3) |  |
 II | 84 (24.8) | 37 (32.7) | 47 (20.8) |  |
 III | 81 (23.9) | 40 (35.4) | 41 (18.1) |  |
 IV | 4 (1.2) | 0 (0) | 4 (1.8) |  |
Histologic grade |  |  |  |  < 0.001 |
 G1–G2 | 212 (62.5) | 52 (46.0) | 160 (70.8) |  |
 G3–G4 | 125 (36.9) | 60 (53.1) | 65 (28.8) |  |
 Unknown | 2 (0.6) | 1 (0.9) | 1 (0.4) |  |
Ishak score | Â | Â | Â | 0.00957 |
 0–4 | 124 (36.6) | 34 (30.1) | 90 (39.8) |  |
 5–6 | 74 (21.8) | 19 (16.8) | 55 (24.3) |  |
 Unknown | 141 (41.6) | 60 (53.1) | 81 (35.8) |  |
Child–Pugh grade |  |  |  | 0.0119 |
 A | 207 (61.1) | 59 (52.2) | 148 (65.5) |  |
 B-C | 21 (6.2) | 5 (4.4) | 16 (7.1) |  |
 Unknown | 111 (32.7) | 49 (43.4) | 62 (27.4) |  |
Vascular invasion | Â | Â | Â | 0.0205 |
 None | 193 (56.9) | 53 (46.9) | 140 (61.9) |  |
 Micro | 84 (24.8) | 30 (26.5) | 54 (23.9) |  |
 Macro | 14 (4.1) | 6 (5.3) | 8 (3.5) |  |
 Unknown | 48 (14.2) | 24 (21.2) | 24 (10.6) |  |
Alpha fetoprotein |  |  |  |  < 0.001 |
 Negative | 143 (42.2) | 25 (22.1) | 118 (52.2) |  |
 Positive | 120 (35.4) | 54 (47.8) | 66 (29.2) |  |
 Unknown | 76 (22.4) | 34 (30.1) | 42 (18.6) |  |
Residual tumor | Â | Â | Â | 0.511 |
 R0 | 301 (88.8) | 99 (87.6) | 202 (89.4) |  |
 R1-R2 | 12 (3.5) | 3 (2.7) | 9 (4.0) |  |
 Unknown | 26 (7.7) | 11 (9.7) | 15 (6.6) |  |
Living status |  |  |  |  < 0.001 |
 Alive | 224 (66.1) | 60 (53.1) | 164 (72.6) |  |
 Dead | 115 (33.9) | 53 (46.9) | 62 (27.4) |  |
Disease status | Â | Â | Â | 0.00479 |
 No | 163 (48.1) | 41 (36.3) | 122 (54.0) |  |
 Yes | 132 (38.9) | 57 (50.4) | 75 (33.2) |  |
 Unknown | 44 (13.0) | 15 (13.3) | 29 (12.8) |  |