Table 2 Cox proportional hazards regression model analysis of overall survival
Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
HR (95% CI) | p | HR (95% CI) | p | |
Age (≥ 65 vs. < 65) | 1.23 (0.85,1.78) | 0.273 | – | – |
Gender (Female vs. Male) | 1.26 (0.87,1.84) | 0.228 | – | – |
Family history of cancer (YES vs. NO) | 1.14 (0.76,1.69) | 0.530 | – | – |
TNM stage (II vs. I) | 1.42 (0.87,2.32) | 0.160 | 1.14 (0.6,2.15) | 0.694 |
TNM stage (III vs. I) | 2.72 (1.78,4.15) |  < 0.001 | 2.03 (1.19,3.47) | 0.010 |
TNM stage (IV vs. I) | 5.44 (1.68,17.63) | 0.005 | 6.91 (2.09,22.89) | 0.002 |
Histologic grade (G3–G4 vs. G1–G2) | 1.14 (0.78,1.67) | 0.489 | – | – |
Ishak score (5–6 vs. 0–4) | 0.87 (0.5,1.5) | 0.612 | – | – |
Child–Pugh grade (B–C vs. A) | 1.66 (0.82,3.36) | 0.159 | – | – |
Vascular invasion (Micro vs. none) | 1.16 (0.72,1.88) | 0.539 | 1.07 (0.61,1.87) | 0.824 |
Vascular invasion (Macro vs. none) | 2.52 (1.14,5.58) | 0.023 | 1.84 (0.8,4.24) | 0.150 |
Alpha fetoprotein (positive vs. negative) | 1.45 (0.92,2.28) | 0.108 | – | – |
Residual tumor (R1–R2 vs. R0) | 1.17 (0.43,3.2) | 0.754 | – | – |
TOP2A (high vs. low) | 1.26 (1.11,1.42) |  < 0.001 | 1.21 (1.04,1.39) | 0.011 |