Fig. 2

Immunohistochemical images of histone H3 methylation and acetylation in mouse stomach cells. A Representative images show that H3K4me3 positive cells increase with treatment duration. B Scatterplot of H-scores based on IHC for H3K4me3-positive cells. C Representative images show H3K9ac-positive cells increase with treatment duration. D Scatterplot of H-scores based on IHC for H3K9ac positive cells. E Representative images show that H3K18ac-positive cells increase with treatment duration. F Scatterplot H-scores based on IHC for H3K18ac-positive cells. G Representative images show that H3K9me3- positive cells decrease with treatment duration. H Scatterplot of H-scores based on IHC for H3K9me3-positive cells. The magnification of all these images is 40x. Inset: 100 × magnification as compared with adjacent cells. The arrow indicates nuclear localization. Data were analysed using one-way ANOVA with Tukey’s multiple comparison post-tests. In each case, images of two mice were shown. The scale bar: 200 µm