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Fig. 1 | Cancer Cell International

Fig. 1

From: The synergistic anticancer effect of the bromodomain inhibitor OTX015 and histone deacetylase 6 inhibitor WT-161 in osteosarcoma

Fig. 1

OTX015 and WT-161 synergistically inhibit the proliferation of OS cells. A, B The effects of either OTX015 or WT-161 on OS cells are dose-dependent and time-dependent. CCK-8 was used to detect cell proliferation in MG63 and U2OS cells after they were treated separately with various doses of OTX015 or WT-161 for 24, 48, or 72 h. Finally, the 3-day IC50 values of the two inhibitors were calculated. C CCK-8 assays of the viability of OS cells at certain concentrations of OTX015/WT-161 and calculated CI values according to the Chou-Talalay method to determine the synergistic effect of OTX015 and WT-161. D OTX015/WT-161 synergistically inhibited the colony formation of MG63 and U2OS cells. Data are means ± SD (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001, compared to DMSO

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Cancer Cell International

ISSN: 1475-2867

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