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Fig. 5 | Cancer Cell International

Fig. 5

From: The synergistic anticancer effect of the bromodomain inhibitor OTX015 and histone deacetylase 6 inhibitor WT-161 in osteosarcoma

Fig. 5

Resistance of β-catenin overexpression to the tumour-suppressing effects of OTX015/WT-161. A CCK-8 was used to detect cell activity in OTX015/WT-161-treated MG63/U2OS cells overexpressing the β-catenin gene. B, C Between the overexpressed β-catenin group and the control group, the inhibitory impact of OTX015/WT-161 on the migration, invasion, and apoptosis of OS cells was contrasted. The ratio of cell penetration and apoptosis was visualized by a bar chart. Data are means ± SD (n = 3). *P < 0.05, **P < 0.01 and ***P < 0.001, compared to DMSO. ns not significant

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