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Fig. 3 | Cancer Cell International

Fig. 3

From: SHC4 promotes tumor proliferation and metastasis by activating STAT3 signaling in hepatocellular carcinoma

Fig. 3

SHC4 positively regulated the migration, invasion and EMT of HCC cells. A Cells migration and invasion abilities in LM3 cells with SHC4 knockdown were determined by transwell assay. Representative image (left panel) and summary bar chart (left panel) are shown. Scale bar, 200 μm. ***P < 0.001, One-way ANOVA. B, C Cells migration and invasion abilities in HepG2 and Huh7 cells with SHC4 overexpression were determined by transwell assay. Representative image (left panel) and summary bar chart (left panel) are shown. Scale bar, 200 μm. ***P < 0.001, Student t test. D, E Expression of EMT markers, E-cadherin, Occludin and Slug in indicated cells were examined by western blotting. F, G Expression of EMT markers, E-cadherin and Occludin were assessed by immunofluorescence staining in indicated cells. Nuclei were visualized with DAPI (blue). Scale bars, 100 μm

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Cancer Cell International

ISSN: 1475-2867

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