Table 1 The correlation between SHC4 expression and clincopathological features in HCC
Clinical variables | No. of patients | SHC4 expression level | P value | |
|---|---|---|---|---|
n = 105 | Low (n = 53) | High (n = 52) | ||
Age (years) | 0.668 | |||
 < 60 | 83 | 41 (49.4%) | 42 (50.6%) |  |
 ≥ 60 | 22 | 12 (54.5%) | 10 (45.5%) |  |
Gender | 0.003 | |||
 Male | 88 | 50 (56.8%) | 38 (43.2%) |  |
 Female | 17 | 3 (17.6%) | 14 (82.4%) |  |
HBsAg | 0.381 | |||
 Positive | 81 | 39 (48.1%) | 42 (51.9%) |  |
 Negative | 24 | 14 (58.3%) | 10 (41.7%) |  |
ALT (U/L) | 0.174 | |||
 ≤ 40 | 75 | 41 (54.7%) | 34 (45.3%) |  |
 > 40 | 30 | 12 (40.0%) | 18 (60.0%) |  |
AST (U/L) | 0.078 | |||
 ≤ 40 | 73 | 41 (56.2%) | 32 (43.8%) |  |
 > 40 | 32 | 12 (37.5%) | 20 (62.5%) |  |
AFP (ng/mL) | < 0.001 | |||
 < 400 | 57 | 38 (66.7%) | 19 (33.3%) |  |
 ≥ 400 | 48 | 15 (31.3%) | 33 (68.8%) |  |
Child–Pugh class | 0.972 | |||
 A | 93 | 47 (50.5%) | 46 (49.5%) |  |
 B | 12 | 6 (50.0%) | 6 (50.0%) |  |
Liver cirrhosis | 0.563 | |||
 No | 31 | 17 (54.8%) | 14 (45.2%) |  |
 Yes | 74 | 36 (48.6%) | 38 (51.4%) |  |
Tumor size(cm) | 0.946 | |||
 ≤ 5 | 34 | 17 (50.0%) | 17 (50.0%) |  |
 > 5 | 71 | 36 (50.7%) | 35 (49.3%) |  |
Tumor number | 0.313 | |||
 Single | 83 | 44 (53.0%) | 39 (47.0%) |  |
 Multiple | 22 | 9 (40.9%) | 13 (59.1%) |  |
Tumor encapsulation | 0.002 | |||
 Yes | 60 | 38 (63.3%) | 22 (36.7%) |  |
 No | 45 | 15 (33.3%) | 30 (66.7%) |  |
Vascular invasion | 0.750 | |||
 Yes | 15 | 7 (46.7%) | 8 (53.3%) |  |
 No | 90 | 46 (51.1%) | 44 (48.9%) |  |
Tumor differentiation | 0.023 | |||
 Well | 64 | 38 (59.4%) | 26 (40.6%) |  |
 Poor | 41 | 15 (36.6%) | 26 (63.4%) |  |
TNM stage | 0.167 | |||
 I–II | 77 | 42 (54.5%) | 35 (45.5%) |  |
 III–IV | 28 | 11 (39.3%) | 17 (60.7%) |  |