Fig. 6
From: MiR-937-3p promotes metastasis and angiogenesis and is activated by MYC in lung adenocarcinoma
MYC was an upstream regulator of miR-937-3p. A Binding motif of MYC in the promoter of miR-937-3p, predicted by JASPAR (http://jaspar.genereg.net/). B The MYC expression level in 40 LUAD tissues and paired adjacent tissues was investigated by qRT-PCR. C MYC was closely related with survival probability. D miR-937-3p gene promoter region. E Chromatin immunoprecipitation (ChIP) assay indicated the MYC binds to the putative binding site upstream of miR-937-3p. F, G The relative expression levels of miR-937-3p and SOX11 responding downregulated MYC were detected by qRT-PCR. H Levels of miR-937-3p and SOX11 was accessed by qRT-PCR after co-transfection. I, J Migration and invasion was determined after co-transfected; scale bars, 50 μm; scale bars, 200 μm. The data expressed as the mean ± SD. (*P < 0.05; **P < 0.01; ***P < 0.001)