Fig. 4

SPDL1 mutation in different cancer types of TCGA. A The alteration frequency with mutation type was displayed. B The mutation sites were displayed. C. The mutation site of R318 in the 3D structure of SPDL1 were displayed. D The potential correlation between mutation status and OS, DSS, DFS, and PFS of UCEC were analyzed by the cBioPortal tool. E Relationships between SPDL1 expression and genomic instability, including TMB, MSI, HRD, LOH, number of neoantigens and the aneuploidy. OS: overall survival. DSS: disease-specific survival. DFS: disease-free survival. PFS: progress-free survival. TMB: tumor mutational burden; MSI: microsatellite instability; HRD: homologous recombination deficiency; LOH: loss of heterozygosity. *p < .05, **p < .01, and ***p < .001