Fig. 2

miR-494-3p is a target of MEG3 in breast cancer cells. A Potential downstream miRNAs of MEG3 along with the B binding sites of miR-494-3p on MEG3 were analyzed by bioinformatics; C miR-494-3p expression in breast cancer cell lines (MDA-MB-231, SUM 149) and normal breast epithelial cell line MCF10A was detected by qRT-PCR; The binding relationship of MEG3 with miR-494-3p was verified by D RIP and E dual-luciferase assays; F MEG3 and miR-494-3p levels in oe-NC group and oe-MEG3 group were detected by qRT-PCR; G MEG3 and miR-494-3p expression, H the cell proliferation, I migration and J invasion in oe-NC  +  NC mimic group, oe-MEG3  +  NC mimic group, and oe-MEG3  +  miR-494-3p mimic group were detected.*p  <  0.05