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Fig. 5 | Cancer Cell International

Fig. 5

From: ERBB3 binding protein 1 promotes the progression of malignant melanoma through activation of the Wnt/ β-catenin signaling pathway

Fig. 5

Knockdown of Ebp1 inhibited the Wnt/β-catenin signaling pathway. ac GEPIA website analysis indicated that the expression level of Ebp1 was positively correlated with CTNNB1 (β-catenin), CCND1 (CyclinD1) and GSK3B (GSK3β). d Western blotting showed that knockdown of Ebp1 down-regulated the expression of β-catenin, CyclinD1 and p-GSK3β. e CHIR99021 reversed the changes caused by Ebp1 knockdown in related proteins. (****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05, vs. shNC ####p < 0.0001, ###p < 0.001, ##p < 0.01, #p < 0.05, vs. shEbp1)

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