Study | Year | Country | Study period | Follow-up duration (months) | Median age (range), years | No.of patients | TNM staging | End points | Study design | Histology | Treatment |
---|---|---|---|---|---|---|---|---|---|---|---|
Raja M. Flores et al.[36] | 2006 | USA | 1998–2005 | 24 | 67 (35–85) | 137 | 0–4 | OS | P | Epithelioid Mixed Sarcomatoid | Surgery |
Adem Koyuncu et al. [28] | 2015 | Turkey | 2008–2012 | 50 | 53.6 ± 10.6 | 60 | 1–4 | OS | R | Epithelial Biphasic Undifferentiated | Multimodality therapy Chemotherapy Best supportive care |
C E Hooper et al.[31] | 2015 | UK | 2008–2011 | 12 | 65–80 | 73 | 1–4 | OS | P | Epithelioid Biphasic Sarcomatoid | Chemotherapy |
Andrea Billé et al.[29] | 2016 | USA | 2000–2013 | 1.2(0–68.2) | 71 (46–90) | 191 | 1–4 | OS | R | Epithelioid Biphasic Sarcomatoid Non-specified | Chemotherapy Radiotherapy Palliative |
Ozlem Ozmen et al.[28] | 2016 | Turkey | 2009–2013 | 2.7–4.7 | 56.2 (28–80) | 51 | 1–4 | OS | R | Epithelial Biphasic Sarcomatoid Unidentified | Best supportive care Chemotherapy Multimodality therapy Pleuropneumonectomy Pleurectomy/decortication |
David O. Hall et al.[32] | 2017 | UK | 2008–2011 | 30 | 69–80 | 73 | 1–4 | OS | P | Epithelioid Sarcomatoid Biphasic | chemotherapy |
Kazuhiro Kitajima et al. [29] | 2017 | Japan | 2007–2014 | 15(1–96) | 66(31–84) | 201 | 1–4 | OS | R | Epithelial Sarcomatoid Biphasic Desmoplastic Others | Non Surgery Group Chemotherapy Chemotherapy and RT |
Berna Akıncı Özyürek et al. [30] | 2018 | Turkey | 2006–2014 | 60 | 56.1 ± 11.4 | 73 | 1–4 | OS | R | Epithelial Biphasic | Chemotherapy Chemotherapy-Pallative radiotherapy chemotherapy |
Hiroshi Doi et al. [25] | 2019 | Japan | 2006–2015 | 24 | 68(31–84) | 188 | 1–4 | OS | R | Epithelioid Non-epithelioid | Chemotherapy radiotherapy |
Filippo Lococo et al. [23] | 2020 | Italy | 2009–2018 | 84 | 69 ± 9 | 141 | 1–4 | OS | R | Epithelial Biphasic Sarcomatoid | Surgery Chemotherapy |
Jun Hyeok Lim et al.[33] | 2020 | Korea | 2009 -2018 | 8.7(3.8–21.9) | 64 (53–71) | 54 | 1–4 | OS | R | Epithelioid Sarcomatoid Biphasic NOS | Surgery Chemotherapy |
Bülent Mustafa Yenigün et al. [22] | 2021 | Turkey | 2008–2018 | 13 (4–55) | 60 (39–84) | 65 | 1–4 | OS | R | Epithelioid Sarcomatoid Biphasic Malignant pleural mesothelioma | Chemotherapy surgery |