Fig. 3

GSDM genes expression involving widely in cancer-related pathways and drug resistance. A Heatmap showing correlation between GSDM genes expression and 10 cancer related pathways. PI3K/AKT, TSC/mTOR and RTK were excluded for they significantly (FDR <  = 0.05) correlated with GSDM genes in no more than 4 of 33 cancer types. Each pathway (activate or inhibit) was represented as a column and each GSDM gene was represented as a row. B Heatmap showing correlation between expression of GSDM genes and drug sensitivity. Each drug was represented as a column and each GSDM gene was represented as a row. Notice that Pearson's correlation coefficient was ranked by GSDME. C Scatter Plot showing the correlation between GSDM genes expression (in horizontal axis) and drug sensitivity (in vertical axis). Only the 15 with the smallest P values were shown. D Protein–protein interaction (PPI) network analysis of GSDM genes. The interaction was downloaded from BioGRID and visualized by Cytoscape software