Table 3 Interaction between circRNAs and K-RAS in the context of cancer (ANTs: adjacent normal tissues)
From: Emerging role of non-coding RNAs in the regulation of KRAS
circRNAs | Diseases | Pattern of expression | Samples | Cell lines | Targets/regulators | Signaling pathways | Function | References |
|---|---|---|---|---|---|---|---|---|
FAT1; HIPK3; ARHGAP; MAN1A2; RHOBTB3; RTN4; SMARCA5 | Colon cancer | Down | – | DLD-1, DKO-1 cells, DKs-8 cells | KRAS | – | circRNAs may serve as promising cancer biomarkers | [74] |
circITGA7 | Colorectal cancer | Down | 69 pairs of colorectal cancer samples and ANTs | s (SW480, RKO, Caco-2, SW620, LoVo, HCT116 and DLD1 | ITGA7 | Ras pathway | circITGA7 represses the proliferation and metastasis of CRC cells via inhibiting the Ras signaling pathway and inducing the transcription of ITGA7 | [73] |
Circ_GLG1 | Colorectal cancer | Up | 40 pairs of CRC tissues and ANTs | HCT116, SW620, and DLD1 cells | miR-622 | Ras pathway | circ_GLG1 promoted tumor cell viability, proliferation, invasion, and migration | [72] |
circFNTA | Bladder cancer | Up | 41 cancer tissues and matched ANTs | SVHUC, BCa cell lines T24, J82, 5637, and UMUC3 | miR-370-3p | Ras pathway | circFNTA induced cell invasion and cisplatin chemo-resistance | [75] |
Circ-MEMO1 | Non-small cell lung cancer | Up | 52 pairs of SCLC tissue samples and ANTs | H1650, PC9, H1299, and A549 | miR-101-3p | miR-101-3p/KRAS Axis | Circ-MEMO1 induced the progression and aerobic glycolysis of lung cancer cells | [76] |