Table 1 Correlation analysis between DFNA5 and relate genes and markers of immune cells in TIMER
From: DFNA5 regulates immune cells infiltration and exhaustion
Desription | Gene markers | COAD | LIHC | LUAD | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
None | Purity | None | Purity | None | Purity | ||||||||
Cor. | P | Cor. | P | Cor. | P | Cor. | P | Cor. | P | Cor. | P | ||
CD8 + T cell | CD8A | 0.37 | *** | 0.267 | *** | 0.182 | *** | 0.138 | 0.0102 | 0.196 | *** | 0.103 | 0.0226 |
CD8B | 0.302 | *** | 0.254 | *** | 0.165 | *** | 0.125 | 0.0201 | 0.172 | *** | 0.104 | 0.0206 | |
T cell (general) | CD3D | 0.35 | *** | 0.223 | *** | 0.234 | *** | 0.198 | *** | 0.226 | *** | 0.119 | * |
CD3E | 0.426 | *** | 0.323 | *** | 0.213 | *** | 0.174 | * | 0.252 | *** | 0.144 | * | |
CD2 | 0.417 | *** | 0.32 | *** | 0.216 | *** | 0.184 | *** | 0.263 | *** | 0.16 | *** | |
B cell | CD19 | 0.255 | *** | 0.133 | * | 0.191 | *** | 0.139 | * | 0.112 | * | 0.002 | *** |
CD79A | 0.318 | *** | 0.18 | *** | 0.208 | *** | 0.165 | * | 0.123 | * | 0.025 | 0.579 | |
Monocyte | CD86 | 0.706 | *** | 0.659 | *** | 0.33 | *** | 0.319 | *** | 0.496 | *** | 0.45 | *** |
CD115 (CSF1R) | 0.711 | *** | 0.662 | *** | 0.265 | *** | 0.256 | *** | 0.497 | *** | 0.442 | *** | |
TAM | CCL2 | 0.67 | *** | 0.623 | *** | 0.242 | *** | 0.203 | *** | 0.439 | *** | 0.391 | *** |
CD68 | 0.543 | *** | 0.489 | *** | 0.329 | *** | 0.296 | *** | 0.462 | *** | 0.412 | *** | |
IL10 | 0.546 | *** | 0.516 | *** | 0.31 | *** | 0.291 | *** | 0.375 | *** | 0.303 | *** | |
M1 Macrophage | INOS (NOS2) | − 0.153 | *** | − 0.208 | *** | 0.0036 | 0.486 | 0.032 | 0.557 | 0.156 | *** | 0.117 | * |
IRF5 | 0.366 | *** | 0.387 | *** | 0.196 | *** | 0,193 | *** | 0.359 | *** | 0.309 | *** | |
COX2(PTGS2) | 0.255 | *** | 0.196 | *** | 0.236 | *** | 0.213 | *** | 0.164 | *** | 0.17 | *** | |
M2 Macrophage | CD163 | 0.725 | *** | 0.683 | *** | 0.194 | *** | 0.17 | * | 0.427 | *** | 0.375 | *** |
VSIG4 | 0.713 | *** | 0.667 | *** | 0.284 | *** | 0.261 | *** | 0.431 | *** | 0.39 | *** | |
MS4A4A | 0.697 | *** | 0.658 | *** | 0.225 | *** | 0.202 | *** | 0.433 | *** | 0.383 | *** | |
Neutrophils | CD66b (CEACAM8) | − 0.101 | * | − 0.0074 | 0.136 | 0.191 | *** | 0.193 | *** | 0.098 | 0.0267 | 0.079 | 0.0787 |
CD11b (ITGAM) | 0.0737 | *** | 0.0717 | *** | 0.327 | *** | 0.328 | *** | 0.496 | *** | 0.453 | *** | |
CCR7 | 0.4 | *** | 0.3 | *** | 0.197 | *** | 0.18 | *** | 0.245 | *** | 0.134 | * | |
Treg | FOXP3 | 0.551 | *** | 0.487 | *** | 0.188 | *** | 0.197 | *** | 0.197 | *** | 0.26 | *** |
CCR8 | 0.562 | *** | 0.51 | *** | 0.315 | *** | 0.302 | *** | 0.283 | *** | 0.208 | *** | |
STAT5B | 0.364 | *** | 0.369 | *** | 0.167 | * | 0.198 | *** | 0.18 | *** | 0.153 | *** | |
TGFβ | 0.698 | *** | 0.624 | *** | 0.291 | *** | 0.268 | *** | 0.474 | *** | 0.419 | *** | |
T cell exhaustion | CD274 | 0.445 | *** | 0.37 | *** | 0.192 | *** | 0.189 | *** | 0.384 | *** | 0.312 | *** |
PDCD1 | 0.386 | *** | 0.294 | *** | 0.208 | *** | 0.169 | * | 0.297 | *** | 0.19 | *** | |
CTLA4 | 0.469 | *** | 0.39 | *** | 0.25 | *** | 0.224 | *** | 0.259 | *** | 0.157 | *** | |
LAG3 | 0.353 | *** | 0.252 | *** | 0.161 | * | 0.136 | *** | 0.218 | *** | 0.144 | * | |
TIM-3 (HAVCR2) | 0.731 | *** | 0.696 | *** | 0.358 | *** | 0.359 | *** | 0.495 | *** | 0.449 | *** | |