Fig. 5

Canagliflozin inhibited thyroid cancer growth in vivo. A The representative image of xenografts. B Tumor weights of canagliflozin treatment group were smaller than those treatment with blank solvent. The xenograft tumors were dissected to detect the weights at 35 days after transplantation. A t-TEST was used to determine statistical significances. C The growth curve of subcutaneous xenograft tumor from TPC-1 cells in nude mice. Tumor size was measured every 2 days. Repeated-measures analysis of variance was used to determine statistical significances. D The body weights of mice administrated with canagliflozin or blank solvent throughout the experimental period. Repeated-measures analysis of variance was used to determine statistical significances. E Canagliflozin had no effect of fasting blood glucose in mice with thyroid cancer allografts. A t-TEST was used to determine statistical significances. F. Ki67 staining of thyroid carcinoma xenografts. G Tunel staining of thyroid carcinoma xenografts