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Fig. 4 | Cancer Cell International

Fig. 4

From: Sestrin2 reduces cancer stemness via Wnt/β-catenin signaling in colorectal cancer

Fig. 4

Sestrin2 inhibits cancer stemness in vivo. A LV-Sestrin2 and LV-GFP cells were transplanted into the hips of mice and after 3 weeks B The tumors were excised. C Tumor volume data (**P = 0.008, *P = 0.02, Mann–Whitney test; connected by medians). D The tumor volumes were measured after removal from the mice (**P = 0.008, Mann–Whitney test; lines showed medians). E The tumor weights were measured (*P = 0.02, Mann–Whitney test; lines showed medians). F HIC of Sestrin2, Ki-67 and β-catenin. G Western blots showing the protein expression of Sestrin2, CD44, Sox2, c-Myc, and β-catenin in mouse tumors. β-Actin was used as a loading control. H A heatmap of the correlations between CD44, β-catenin (CTNNB1), CXCR4, c-Myc (MYC), OCT4 (POU5F1), SOX2 and Sestrin2 (SESN2). Red represents a positive correlation, blue represents a negative correlation, and darker colors represent stronger correlations. Asterisks represent levels of significance (*P < 0.05, **P < 0.01, T test)

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