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Fig. 2 | Cancer Cell International

Fig. 2

From: Long non-coding RNAs as the critical regulators of epithelial mesenchymal transition in colorectal tumor cells: an overview

Fig. 2

Role of lncRNAs in EMT regulation via MAPK and TGFβ signaling pathways in CRC. PVT1 suppressed the growth and metastatic ability of cancer cells via miR-216a-5p sponging that resulted in YBX1 up regulation. SNHG16 regulated CRC cell proliferation, migration, invasion, and EMT via the miR-124-3p/MCP-1 axis. SNHG6 activated TGF-β/Smad signaling by binding UPF1 that increased tumor cell proliferation and metastasis. TUG1 promoted carcinogenesis and EMT in colon cancer by stimulating the P38MAPK/Hsp27 axis. BANCR promoted CRC cell migration by EMT induction through the MEK/ERK pathway. NNT-AS1 regulated tumor cell proliferation and invasion by reducing the activity of MAPK/ERK pathway to suppress EMT. (Created with www.BioRender.com)

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Cancer Cell International

ISSN: 1475-2867

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