Sample no. | cfDNA qPCR | T790M ddPCR Detection positive (≥ 2 events/assay) | T790M CRISPR-CPPC assay Detection positive (≥ 6 events/assay) | Tissue or other samples qPCR | NGS | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Result | Events | Wild | Allele frequency (%) | Result | Events | Wild | Allele frequency (%) | Result | Result | Result | |
3 | ND | 3 | 560 | 0.5 | Positive | 353 | 4570 | 7.2 | Positive | L858R | NA |
4 | Positive | 1 | 238 | 0.4 | ND | 102 | 1811 | 5.3 | Positive | Exon19 del | T790M 2.4% |
7 | Positive | 0 | 533 | 0.0 | ND | 6 | 1228 | 0.5 | Positive | L858R | NA |
8 | Positive | 3 | 430 | 0.7 | Positive | 7 | 1556 | 0.4 | Positive | Exon19 del | NA |
9 | Positive | 5 | 438 | 1.1 | Positive | 8 | 1215 | 0.7 | Positive | Exon19 del | NA |
29 | ND | 3 | 1170 | 0.3 | Positive | 9 | 2568 | 0.3 | Positive | Exon19 del | NA |
30 | ND | 2 | 386 | 0.5 | Positive | 38 | 2766 | 1.4 | Positive | L858R | NA |
32 | ND | 0 | 302 | 0.0 | ND | 2 | 1978 | 0.1 | ND | Exon19 del T790M from lung tissue | T790M 0.5% |
34 | ND | 1 | 310 | 0.3 | ND | 24 | 3816 | 0.6 | Positive | Exon19 del T790M from lung tissue | NA |
45 | Positive | 6 | 205 | 2.8 | Positive | 28 | 1220 | 2.2 | Positive | Exon19 del | NA |
46 | Positive | 2 | 114 | 1.7 | Positive | 158 | 7316 | 2.1 | Positive | Exon19 del | NA |
48 | ND | 0 | 71 | 0.0 | ND | 7 | 2119 | 0.3 | Positive | Exon19 del | T790M 0.1% |
54 | Positive | 0 | 31 | 0.0 | ND | 274 | 3874 | 6.6 | Positive | L858R | NA |
58 | ND | 0 | 139 | 0.0 | ND | 12 | 6052 | 0.2 | Positive | Exon19 del | T790M 0.2% |
59 | ND | 0 | 11 | 0.0 | ND | 10 | 5294 | 0.2 | Positive | L858R T790M from pleural fluid | ND |
60 | Positive | 1 | 137 | 0.7 | ND | 562 | 6343 | 8.1 | Positive | Exon19 del | T790M 2.1% |