Fig. 7

Validation of lncRNA MSTRG.292666.16-hsa-miR-6836-5p-MAPK8IP3 in the exosomes. In the plasma-derived exosomes, lncRNA MSTRG.292666.16, and MAPK8IP3 were upregulated, while hsa-miR-6836-5p was significantly downregulated in the resistant plasma-derived exosomes (A). In the cell-derived exosomes, MSTRG.292666.16, and MAPK8IP3 were upregulated, whereas hsa-miR-6836-5p was downregulated in the exosomes from M2 type TAMs (B). All these implied that the level trend of MSTRG.292666.16, miR-6836-5p and MAPK8IP3 in the exosomes determined by RT-qPCR were consistent with those measured by sequencing