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Fig. 3 | Cancer Cell International

Fig. 3

From: Overexpression of CBS/H2S inhibits proliferation and metastasis of colon cancer cells through downregulation of CD44

Fig. 3

Overexpression of CBS attenuates CRC cell growth and liver metastasis in vivo. A Typical macroscopic pictures of xenograft tumors from subcutaneous injection in HT-29 control and CBS-overexpressing group (n = 6). B Tumor growth trend in HT-29 control and CBS-overexpressing group (*p < 0.05). C Immunohistochemistry results of subcutaneous xenografts from HT-29 control and CBS-overexpressing group. Scale bar, 50 μm. D Statistical analysis of immunohistochemistry results of subcutaneous xenograts from HT-29 control and CBS-overexpressing group based on H-score. (***p < 0.001). E Typical macroscopic pictures of liver specimens harvested at 8 weeks after intrasplenic injection in HT-29 control and CBS-overexpressing group (n = 6). F Statistical analysis of macroscopic metastatic tumor nodules on the liver surface tissues in HT-29 control and CBS-overexpressing group (*p < 0.05). G Typical microscopic pictures of liver metastatic areas in HT-29 control and CBS-overexpressing group. White arrows indicate metastatic areas. Scale bar, 50 μm

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