Fig. 5

miR-223-3p regulates the proliferation, migration and invasion of GC cells by targeting SORBS1. A miR-223-3p and SORBS1expression in each transfection group after 48 h transfection (BGC-823 cells: n = 3; p = 0.0017; p < 0.001, p < 0.001; p < 0.001, AGS cells: p = 0.0025; p = 0.0017, p = 0.0003; p = 0.0004); B SORBS1 expression in each transfection group after 48-h transfection (n = 3; p = 0.0003; p = 0.0002, n = 3; p = 0.0002; p = 0.0014); C The cell activity of each transfection group (n = 3; p = 0.0014; p = 0.0051, n = 3; p = 0.0014; p = 0.0187); D The ability of cell colony formation in each transfection group (n = 3; p = 0.0015; p = 0.0158, n = 3; p = 0.0098; p = 0.0004); E, F The cell migration and invasion in each transfection group (migration: n = 3; p = 0.0085; p = 0.0073, n = 3; p = 0088; p = 0.0138, invasion: n = 3; p = 0.0073; p = 0.0093, n = 3; p = 0.0002; p < 0.0001). G, H Cell apoptosis and cell cycle in each transfection group (apoptosis: n = 3; p < 0.0001; p < 0.0001, p = 0.0001; p = 0.0001, cell cycle: n = 3; p = 0.0370; p = 0.0225, p = 0.0085; p = 0.0217). *p < 0.05; **p < 0.01; ***p < 0.001