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Fig. 6 | Cancer Cell International

Fig. 6

From: miR-223-3p carried by cancer-associated fibroblast microvesicles targets SORBS1 to modulate the progression of gastric cancer

Fig. 6

miR-223-3p in MVs derived from CAFs promotes malignant progression of GC in vivo. A Appearance pictures and weight of subcutaneous tumor masses of mice (n = 5; p < 0.0001; p < 0.0001); B Volume and growth of subcutaneous tumor masses of transplanted mice in the 3 groups (n = 5; p = 0.0013; p = 0.0196); C miR-223-3p and SORBS1levels in cancer tissue of 3 groups of mice (n = 3; p < 0.0001; p ≤ 0.0001, p = 0.0002; p = 0.0001); D Expression level of Ki-67 in tumor tissue of transplanted mice detected by IHC; E The expression levels of EMT-related proteins and SORBS1 in the tumor tissue of transplanted mice (n = 3; p = 0.0002; p ≤ 0.0001, p = 0.0005; p = 0.0001, p = 0.0034; p = 0.0002). *p < 0.05; **p < 0.01; ***p < 0.001

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