Fig. 2

HOXA7 upregulation promotes KRAS mutant CRC metastasis in immunocompetent mice. A Western blotting analyses of HOXA7 expression, and the number indicates relative gray values. B–G In vivo assays showing that HOXA7 overexpression can promote KRAS mutant CRC metastasis. B Bioluminescent images showing the presence of metastases in mice 9 weeks after implantation with CT26-HOXA7 cells and CT26-control cells. C Bioluminescent signals in each group. D Overall survival of the BALB/C mice in each group. E The incidence of lung and liver colonization. F The number of lung and liver metastatic nodules. G HE staining was used to identify metastatic lung and liver nodules at 9 weeks. *P < 0.05