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Fig. 4 | Cancer Cell International

Fig. 4

From: HOXA7 promotes the metastasis of KRAS mutant colorectal cancer by regulating myeloid-derived suppressor cells

Fig. 4

Downregulation of CXCL1 expression can inhibit HOXA7-mediated KRAS mutant CRC metastasis. A HOXA7 and CXCL1 expression in the indicated cells as determined by real-time PCR analysis (the Ct value for the indicated gene was shown in Table 3). BE CXCL1 knockdown can reduce HOXA7-mediated KRAS mutant CRC metastasis in CT26-HOXA7 cells. B Bioluminescence images and bioluminescence signals in the CT26-HOXA7-shcontrol and CT26-HOXA7-shCXCL1 groups at 9 weeks. C The number of lung and liver metastatic nodules in each group at 9 weeks. D Overall survival of the BALB/C mice in each group. E HE staining was used to identify metastatic lung and liver nodules at 9 weeks. F The expression of HOXA7, CD11b and CD8 of primary tumor in CT26-HOXA7-shcontrol and CT26-HOXA7-shCXCL1 groups was analyzed by IHC. G The infiltration of MDSCs and CD8+ T cells in CT26-HOXA7-shcontrol and CT26-HOXA7-shCXCL1 groups was analyzed by flow cytometry. All the data are presented as the mean ± s.d. *P < 0.05

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