The emerging role non-coding RNAs in B cell-related disorders

Ghafouri-Fard, Soudeh; Khoshbakht, Tayyebeh; Hussen, Bashdar Mahmud; Taheri, Mohammad; Jamali, Elena

doi:10.1186/s12935-022-02521-1

Table 3 CircRNAs and B cells functions

From: The emerging role non-coding RNAs in B cell-related disorders

circRNA	Expression pattern	Disease	Sample	Cell line	Interaction	Signaling pathway	Function	References
Human studies
Circ_OTUD7A	↑	DLBCL	50 pairs of DLBCL tissues and ANCTs	U2932, TMD8 and OCI-Ly3 LBCL cell lines and GM12878 normal human B lymphocytes	↓ miR-431-5p, ↑ FOXP1	–	∆ Circ_OTUD7A: ↓ proliferation, metastasis, ↑ cell cycle arrest and apoptosis	[147]
circ-APC	↓	DLBCL	80 pairs of DLBCL and para-cancerous tissues, plasma samples from 27 DLBCL patients and 16 healthy controls, nude mice	SUDHL-3, U2932, TMD8, OCI-Ly3 and L428 human DLBCL cell lines and GM12878 normal human B lymphocytes	miR-888, APC, DNA demethylase TET1	Wnt/β-catenin signaling pathway	↑ CircCFL1: ↓ proliferation and tumor growth	[149]
circBCL11B	↑	AML	61 patients with AML and 16 healthy samples, GEO dataset: GSE137851	–	–	–	∆ circBCL11B: ↓ proliferation, ↑ apoptosis	[151]
circCDYL	↑	MCL	18 patients with MCL and 17 healthy controls	HEK293T cells and Z138 human MCL cell line	five miRNAs (hsa-miR-129-5p, hsa-miR-3163, hsa-miR-4662a-5p, hsa-miR-101-3p, and hsa-miR-186-5p), three lncRNAs (MALAT1, NEAT1, and XIST), and five mRNAs (NOTCH1, FMR1, ABCB1, TWIST1, and VEGFA)	–	∆ circCDYL: ↓ proliferation	[152]
circ_0132266	↓	CLL	30 patients with CLL and 30 healthy controls	MEC-1, JVM-3 and HEK-293 T	↑ miR-337-3p, ↓ PML	–	↑ circ_0132266: ↓ proliferation	[150]
circ_0005774	↑	AML	20 patients with AML and 20 healthy controls	HL-60 and NB4 cells	↓ miR-192-5p, ↑ ULK1	–	∆ circ_0005774: ↓ proliferation and viability, ↑ apoptosis	[153]
circ-Smad5	↓	DLBCL	–	JB6 and 293 T cell lines	–	Wnt/β-catenin/Lef1 signaling pathway	∆ circ-Smad5: ↑ cell cycle progression and activated Wnt/β-catenin/Lef1 signaling pathway	[154]
circ_0009910	↑	AML	35 patients with AML and 35 healthy controls	HL-60 and MOLM-13	↓ miR-5195-3p and ↑ GRB10	–	∆ circ_0009910: ↓ proliferation and cell cycle progression, ↑ apoptosis	[155]
circ-CBFB	↑	CLL	47 patients with CLL and 21 healthy controls	HEK293T and MEC-1 human CLL cell line	↓ miR-607, ↑ FZD3	↑ Wnt/β-catenin pathway	∆ circ-CBFB: ↓ proliferation and cell cycle progression, ↑ apoptosis	[156]
Murine studies
CircCFL1	↑	DLBCL	female BALB/c nude mice	OCI-Ly7 and OCI-Ly3 human DLBCL cell lines	↓ miR-107, ↑HMGB1	–	↑ CircCFL1, ↑ proliferation, migration, tumor volume and weight	[148]

ANCTs, adjacent non-cancerous tissues; AML, acute myeloid leukemia; HSPC, hematopoietic stem and progenitor cell; MCL, Mantle cell lymphoma; CLL, chronic lymphocytic leukemia

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