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Table 1 Functional characteristics of SNHG17 in various cancers

From: Long noncoding RNA SNHG17: a novel molecule in human cancers

Cancer Types Expression Roles Assessed Cell Lines Phenotypes Affected Related Genes References
Oral squamous cell carcinoma UP Oncogenic YD-38, SCC-9 Proliferation, cell viability, apoptosis miR-384, ELF1, CTNNB1, Wnt/β-catenin [39]
Oral squamous cell carcinoma UP Oncogenic Tca8113, CAL-27 Proliferation, invasion, migration, apoptosis MiR-375, PAX6 [40]
Tongue squamous cell carcinoma UP Oncogenic Tca8113, CAL-27 Proliferation, invasion, migration, xenograft growth MiR-876, SP1 [41]
Esophageal squamous cell carcinoma UP Oncogenic TE-1, Eca109 Proliferation, invasion, EMT, xenograft growth MiR-338-3p, SOX4 [45]
Non-small cell lung cancer UP Oncogenic A549, PC9 Proliferation, migration, apoptosis FOXA1, XAF1, BIK [14]
Lung adenocarcinoma UP Oncogenic A549, H1299 Proliferation, migration, invasion, apoptosis Caspase-3, Bax, Bcl-2, miR-485-5p, WLS [48]
Lung adenocarcinoma UP Oncogenic A549, H1299 Proliferation, migration, invasion, EMT MiR-193a-5p, NETO2 [49]
Breast cancer UP Oncogenic MCF-7, MDA-MB-231 Proliferation, migration, invasion miR-124-3p [12]
Gastric cancer UP Oncogenic GES-1, SGC-7901, AGS Repair of DNA damage NONO, Ku80, miR-3909, Rad51, RING1 [11]
Gastric cancer UP Oncogenic AGS, HGC-27, SGC-7901 Proliferation, invasion, migration, cell cycle, apoptosis, xenograft growth EZH2, P15, P57 [15]
Colorectal cancer UP Oncogenic DLD-1, HCT116 Proliferation, cell viability, cell cycle, apoptosis, xenograft growth EZH2, P57 [13]
Rectal cancer UP Oncogenic SW837, SW1463 Proliferation, apoptosis, xenograft growth MiR-361-3p, STC2 [54]
Colon adenocarcinoma UP Oncogenic HT29, T84 Proliferation, invasion, migration, EMT, xenograft growth MiR-375, CBX3, E-cadherin, Vimentin, N-cadherin [53]
Colorectal adenocarcinoma UP Oncogenic RKO, HCT116 Proliferation, migration, cell viability, angiogenesis MiR-23a-3p, CXCL12 [55]
Hepatocellular carcinoma UP Oncogenic HepG2, Huh7 Proliferation, invasion, migration, EMT, xenograft growth, lung metastasis E-cadherin, Vimentin, miR-3180-3p, RFX1 [16]
Hepatocellular carcinoma UP Oncogenic HepG2, SF, SNU-449, HCCLM9 Proliferation, cell cycle, xenograft growth, DNA replicating LRPRC, c-MYc, ppRb, CDK2, CDK4 [59]
Hepatocellular carcinoma UP Oncogenic PLC, SMMC-7721, Hep3B, HuH-7 Proliferation, migration, apoptosis ERH, TBCA, TDO2, PDK4 [60]
Pancreatic cancer UP Oncogenic PANC-1, AsPC-1 Proliferation, cell viability, invasion, migration, apoptosis, xenograft growth Caspase-8, Bak, PPARγ, VEGF, ZEB1, BMP, ISG12a, GDNF [62]
Prostate cancer UP Oncogenic C4-2, LNCaP Proliferation, cell viability, invasion, apoptosis, xenograft growth, chemotherapeutic resistance Caspase-3, β-actin, TCF [66]
Prostate cancer UP Oncogenic PC-3, VCaP Proliferation, invasion, migration, EMT, apoptosis, xenograft growth SNORA71B, STAT5A, E-cadherin, N-cadherin [67]
Castration-resistant prostate cancer UP Oncogenic C4-2, PC-3 Proliferation, invasion, migration, xenograft growth MiR-144, CD51 [68]
Renal cell carcinoma UP Oncogenic ACHN, 786-O Proliferation, invasion, migration, cell viability, apoptosis, xenograft growth MiR-328-3p, H2AX [64]
Ovarian cancer UP Oncogenic OVCAR-3, PEO1 Proliferation, cell cycle, apoptosis, xenograft growth STAT3, CTNNB1, miR-214-3p, CDK6 [70]
Ovarian cancer UP Oncogenic OVCAR-3, SKOV3 Proliferation, invasion FOXA1 [71]
Cervical cancer UP Oncogenic SiHa, HeLa Proliferation, invasion, migration, apoptosis MiR-375-3p [86]
Glioma UP Oncogenic LN229, U251 Proliferation, invasion, migration MiR-23b-3p, ZHX1 [74]
Glioma UP Oncogenic U87, U251 Proliferation, cell viability, apoptosis, xenograft growth Caspase3, Caspase9, Bax, YY1, miR-506-3p, CTNNB1, Wnt/β-catenin [75]
Astrocytoma UP Oncogenic LN215, U138 Proliferation, invasion, migration, stemness, chemotherapeutic resistance MiR-876-5p, ERLIN2 [76]
Melanoma UP Oncogenic CHL-1, A375 Proliferation, invasion, migration Caspase3, Caspase9, STAT3, PI3K/AKT [77]
Osteosarcoma UP Oncogenic CAFs, HOS, SJSA-1 Proliferation, migration,apoptosis, xenograft growth MiR-2861, MMP2 [18]