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Table 2 Prognostic role of miR-630 in cancers (ANCTs adjacent non-cancerous tissues, BCLC Barcelona-Clinic Liver Cancer)

From: The importance of miRNA-630 in human diseases with an especial focus on cancers

Samples

Kaplan Meier

Multivariate Cox analysis

Refs.

33 renal cell carcinoma (RCC) tissues

–

Up-regulation of miR-630 was correlated with TNM stage class I

[36]

92 RCC tissues

Up-regulation of miR-630 was correlated with the unfavorable prognosis of patients

Up-regulation of miR-630 was correlated with the grade, lymph node metastasis, and distant metastasis

[33]

53 ovarian cancer (OC) tissues

–

High level of miR-630 was correlated with higher stages and lymph node metastasis

[12]

114 tumor tissues of non-small cell lung cancer (NSCLC)

Low level of miR-630 and high level of BCL2 correlated with weak outcomes in the patients

The advanced stage of tumors was associated with low level of miR-630

[34]

42 pairs of hepatocellular carcinoma (HCC) tumors and ANCTs

There was a positive correlation between miR-630 expression and the patient’s prognosis

There was a positive correlation between miR-630 expression and advanced stage (II–III), micro and macro-vascular invasion

[14]

97 HCC patient tissues

Low level of miR-630 was associated with the poor prognosis

There was a correlation between low levels of miR-630 with metastasis probability, incomplete encapsulation, advanced edmondson stage, advanced TNM stage, advanced BCLC stage, high tumor number, and vascular invasion possibility

[15]

46 NSCLC tumor samples

Low level of miR-630 was correlated with a worse prognosis

Low level of miR-630 usually observed in advanced stages (II, III, and IV)

[37]

Tumor tissue from 118 gastric cancer (GC) patients

Low level of miR-630 was associated with the poor prognosis

There was correlation between miR-630 expression with tumor size, lymph node metastasis, depth of invasion, and stage

[18]

236 GC tumors (intestinal and diffuse type)

miR-630 up-regulation was associated with poor overall survival

miR-630 over-expression correlated with invasion, lymph node and distant metastasis, and TNM stage

[35]

147 osteosarcoma tissues

Low level of miR-630 was associated with the worse prognosis

There was a correlation between low miR-630 expression with higher stage and distant metastasis

[29]

Peripheral blood from 58 esophageal cancer patients

Low level of miR-630 was associated with poor prognosis

The levels of miR-630 were associated with disease course, stage, differentiation degree, and metastasis

[31]

44 esophageal squamous cell carcinoma (ESCC) tumors

Low level of miR-630 was associated with the unfavorable prognosis

The levels of miR-630 were associated with tumor range, lymphatic metastasis, and stage

[32]

116 pairs of bladder urothelial carcinoma and ANCTs, 42 normal tissue

High level of miR-630 was associated with the worse prognosis

There was a correlation between high miR-630 level with advanced TNM stage, higher grade and, lymph node metastasis

[38]

206 colorectal cancer (CRC)

High miR-630 expression was associated with poor overall survival

High expression of miR-630 correlated with tumor invasion (T3+T4), lymph node metastasis, distant metastasis, and advanced TNM stage

[39]