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Table 1 Patient’s characteristics

From: Microbial and molecular differences according to the location of head and neck cancers

Variables RNA (N = 519) Variables DNA (N = 172)
Oral (314) Non-oral (205) P-value Oral (115) Non-oral (57) P-value
Age  < 66 202 (64%) 154 (75%) 0.030* Age  < 66 80 (70%) 43 (75%) 0.476
 ≥ 66 111 (35%) 51 (25%)  ≥ 66 35 (30%) 14 (25%)
NA 1 (0%) NA
Gender Female 102 (32%) 34 (17%) 8.698E-05*** Gender Female 41 (36%) 2.372E-06***
Male 212 (68%) 171 (83%) Male 74 (64%) 51 (89%)
HPV status positive 32 (10%) 65 (32%) 1.623E-09*** HPV status Positive 16 (14%) 31 (54%) 5.201E-08***
negative 282 (90%) 140 (68%) Negative 99 (86%) 26 (46%)
NA 1 (0%) NA
Clinical Stage Stage I 12 (4%) 8 (4%) 3.998E-03**
4.998E-04***
Clinical stage Stage I 4 (3%) 1.100E-03**
Stage II 76 (24%) 22 (11%) Stage II 29 (25%) 9 (16%)
Stage III 65 (21%) 40 (20%) Stage III 29 (25%) 7 (12%)
Stage IVA 146 (46%) 118 (58%) Stage IVA 53 (46%) 35 (61%)
Stage IVB 4 (1%) 7 (3%) Stage IVB 4 (7%)
Stage IVC 3 (1%) 4 (2%) Stage IVC 1 (2%)
NA 8 (3%) 6 (3%) NA 1 (2%)
Pathologic Stage StageI 21 (7%) 6 (3%) Pathologic stage Stage I 9 (8%) 2 (4%) 2.733E-05***
Stage II 54 (17%) 20 (10%) Stage II 22 (19%) 4 (7%)
Stage III 56 (18%) 25 (12%) Stage III 18 (16%) 8 (14%)
Stage IVA 154 (49%) 98 (48%) Stage IVA 56 (49%) 19 (33%)
Stage IVB 7 (2%) 5 (2%) Stage IVB 1 (1%) 2 (4%)
Stage IVC 1 (0%) Stage IVC
NA 22 (7%) 50 (24%) NA 9 (8%) 22 (39%)
Race American Indian or Alaska native 1 (0%) 1 (0%) 0.029* Race American Indian or Alaska native 0.379
Asian 10 (3%) 1 (0%) Asian 2 (2%)
Black or African American 22 (7%) 26 (13%) Black or African American 6 (5%) 6 (11%)
White 270 (86%) 173 (84%) White 105 (91%) 51 (89%)
NA 11 (4%) 4 (2%) NA 2 (2%)
Alcohol History Yes 202 (64%) 144 (70%) 0.393 Alcohol history Yes 72 (63%) 48 (84%) 1.913E-03**
NO 105 (33%) 57 (28%) NO 41 (36%) 7 (12%)
NA 7 (2%) 4 (2%)   NA 2 (2%) 2 (4%)
Pack Years Smoked 30 <  52 (17%) 37 (18%) 0.014* Pack years smoked 30 <  16 (14%) 12 (21%) 0.174
30≥ 111 (35%) 95 (46%) 30 ≥  42 (37%) 25 (44%)
NA 151 (48%) 73 (36%) NA 57 (50%) 20 (35%)
  1. AJCC version:4–7th, P < 0.05 ** P < 0.01 ***P < 0.001, HNSCC, head and neck squamous cell carcinoma; NA not available
  2. Chi-squared test was done for gender, HPV status, Pack Years Smoked and Fisher’s exact-test was done for Age, Clinical Stage, Pathologic Stage, Race, Alcohol History