Table 3 DAVID gene-annotation enrichment analysis of KEGG pathway
From: Microbial and molecular differences according to the location of head and neck cancers
| Â | ID | KEGG pathway | Count | P-value | FDR | Genes |
|---|---|---|---|---|---|---|
Positively correlated genes in oral cancer | hsa05020 | Prion disease | 10 | 9.21E-07 | 9.120E-05 | STIP1, PSMA6, TUBA1C, PSMD12, TUBB6, TUBB2A, IL1B, PPIF, TUBB4B, TUBA4A |
hsa05010 | Alzheimer disease | 9 | 1.15E-04 | 2.412E-03 | PSMA6, TUBA1C, PSMD12, TUBB6, TUBB2A, IL1B, PPIF, TUBB4B, TUBA4A | |
hsa05132 | Salmonella infection | 8 | 5.09E-05 | 2.412E-03 | TUBA1C, TUBB6, TUBB2A, CXCL8, IL1B, TUBB4B, DYNLL1, TUBA4A | |
hsa05012 | Parkinson disease | 8 | 7.74E-05 | 2.412E-03 | PSMA6, TUBA1C, PSMD12, TUBB6, TUBB2A, PPIF, TUBB4B, TUBA4A | |
hsa05130 | Pathogenic Escherichia coli infection | 7 | 1.22E-04 | 2.412E-03 | TUBA1C, TUBB6, TUBB2A, CXCL8, IL1B, TUBB4B, TUBA4A | |
Positively correlated genes in oral cancer | hsa05168 | Herpes simplex virus 1 infection | 39 | 6.31067961 | 3.342E-08 | ZNF155, ZNF132, ZNF550, ZNF195, ZNF606, ZNF84, ZNF823, ZNF547, ZNF205, ZNF766, ZNF600, ZNF226, ZNF302, EIF2B1, ZNF566, ZNF620, ZNF224, ZNF564, ZNF443, ZNF584, ZNF441, ZNF141, ZNF140, ZNF283, BST2, IRF3, ZNF519, IRF7, SRSF2, SRSF3, ZNF337, ZNF557, SRSF5, ZNF780A, SRSF6, SRSF7, ZNF112, ZNF530, ZNF354B |
hsa03040 | Spliceosome | 22 | 3.55987055 | 1.454E-09 | PRPF38B, HSPA1L, RBM8A, CCDC12, THOC1, MAGOHB, LSM5, LSM4, LSM2, XAB2, HNRNPM, PHF5A, PRPF18, TRA2B, MAGOH, SRSF2, SRSF3, PRPF31, SRSF5, SRSF6, SRSF7, SRSF10 | |
Negatively correlated genes in non-oral cancer | hsa04151 | PI3K-Akt signaling pathway | 59 | 6.5701559 | 1.870E-15 | ITGB1, ATF2, FLT1, ITGB5, IRS1, ITGB4, FLT4, ITGB3, TNC, LAMC2, LAMC1, IGF1R, RPTOR, GYS1, PPP2R5E, CREB3L2, KDR, ITGAV, ITGB6, IL6R, YWHAG, PDGFRB, MAP2K1, ITGA3, ITGA1, F2R, PRKCA, OSMR, COL4A2, PIK3CA, COL4A1, COL6A1, COL6A3, ITGA7, ITGA6, ITGA5, ITGA9, CREB5, LAMA2, LAMA4, LAMA3, PDGFB, LPAR3, LPAR4, THBS2, THBS1, EGFR, RELA, RXRA, PDGFC, MAPK1, ANGPT2, LAMB3, FN1, PPP2R3A, COL1A1, COL1A2, ITGA11, TEK |
hsa04510 | Focal adhesion | 58 | 6.45879733 | 1.455E-27 | ITGB1, FLT1, ITGB5, ITGB4, FLT4, ITGB3, TNC, LAMC2, LAMC1, ACTB, IGF1R, MYLK, KDR, ITGAV, ITGB6, PDGFRB, MAP2K1, ITGA3, ACTN1, ITGA1, PRKCA, ACTN4, COL4A2, PIK3CA, COL4A1, COL6A1, RAPGEF1, COL6A3, ITGA7, ITGA6, ITGA5, TLN1, CRK, VCL, ITGA9, LAMA2, ROCK2, LAMA4, PXN, LAMA3, PDGFB, THBS2, THBS1, EGFR, PDGFC, FLNA, MAPK1, FLNB, FLNC, PAK2, LAMB3, CAV1, FN1, PARVA, COL1A1, COL1A2, ITGA11, ZYX | |
hsa04810 | Regulation of actin cytoskeleton | 42 | 4.67706013 | 3.317E-13 | ITGB1, CYFIP1, ITGB5, ROCK2, ITGB4, ITGB3, ARPC1B, PXN, PDGFB, WASL, LPAR4, IQGAP1, EGFR, ACTB, SLC9A1, MYLK, GNA12, PDGFC, MAPK1, ITGAV, ITGB6, PAK2, PDGFRB, MAP2K1, ITGA3, ACTN1, LIMK1, ITGA1, F2R, FN1, MSN, ACTN4, ENAH, PIK3CA, ITGA11, MYH9, ITGA7, ITGA6, ITGA5, CRK, VCL, ITGA9 | |
hsa04512 | ECM-receptor interaction | 30 | 3.34075724 | 1.945E-16 | ITGB1, LAMA2, ITGB5, ITGB4, LAMA4, ITGB3, LAMA3, TNC, LAMC2, LAMC1, THBS2, THBS1, ITGAV, ITGB6, LAMB3, ITGA3, ITGA1, FN1, HSPG2, COL1A1, COL1A2, COL4A2, COL4A1, COL6A1, ITGA11, COL6A3, ITGA7, ITGA6, ITGA5, ITGA9 | |
hsa05414 | Dilated cardiomyopathy | 25 | 2.78396437 | 6.870E-11 | ITGB1, LAMA2, ITGB5, ITGB4, ITGB3, ATP2A2, ADCY1, ADCY7, ACTB, SGCD, SGCA, ITGAV, ITGB6, TPM4, ITGA3, TPM1, ITGA1, ACTC1, DES, ITGA11, MYL3, ITGA7, ITGA6, ITGA5, ITGA9 |