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Fig. 2 | Cancer Cell International

Fig. 2

From: Interaction between non-coding RNAs, mRNAs and G-quadruplexes

Fig. 2

 A schematic representation of the interaction between G-quadruplex structure of pre-miRNA-1229 and endolysosomal processing in microglial cells in Alzheimer’s disease. Previous studies have authenticated that SORL1 could play an effective role in binding Aβ and facilitating its degradation in the lysosomes [46]. As an illustration, recent study has detected that Pre-miRNA-1229 rs2291418 variant, which is significantly associated with Alzheimer’s diseases, alters its structure to the extended hairpin structure and enhances SORL1 transcription. SORL1 is a protein that is responsible for the processing and trafficking of Aβ in AD [45]

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