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Table 2 The presence and function of G-quadruplexes in mRNA coding genes

From: Interaction between non-coding RNAs, mRNAs and G-quadruplexes

Protein-coding genes Location Ligands Cell line Clinical samples/animal models References
Task3 5′-UTR DHX36 HEK293 C57Bl/6 wild-type mice [53]
BAG-1 5′-UTR SNRPA HCT-116 [54]
NRXN2α 5′-UTR SH-SY5Y, SK-N-SH, U87MG, HEK293 [55]
TGFβ2 5′-UTR MCF-7 [56]
ARPC2 5′-UTR HEK293, MCF7 [57]
KNCJ11 3′-UTR miR-331-3p, TMPyP4 HEK-293A Cardiomyocytes isolated from newborn SD rats [51]
PSD-95 3′-UTR FMRP, miR-125a [52]
NRAS 5′-UTR ZnAPC MCF-7 [58]
5′-UTR DDX3X, DDX5, DDX17, GRSF1, NSUN5 HeLa, Flp-In T-REx 293 [59]
Hnf4a1 5′-UTR HEK293T, HepG2-C3A [60]
Bcl‐2 5′-UTR HEK293, A‐375 [61]
SMNDC1 5′-UTR FMRP E17 mouse brain lysate [62]
FADS2 3′-UTR mir331-3p HEK293, Huh7, HCT116 [63]
PITX1 3′-UTR RHAU [64]
p53 3′-end DHX36 A549, HCT116 WT, p53 KO cells [65]
SNCA 5′-UTR HEK-293, SK-N-SH, Neuro-2a [66]
NRF2 5′-UTR EF1a HEK293, HeLa [67]
ADAM10 5′-UTR A methyl-quinolinium derivative HeLa, HEK-APP [68]
VEGF 5′-UTR 360A, Phen-DC HeLa [69]
NR2B 3′-UTR FMRP E17 mouse brain lysate [70]
Nkx2-5 5′-UTR RHAU H9C2, 293T, COS7, E14.5 cardiomyocytes Rhau conditional KO mice [71]
APP 3′-UTR HeLa, HEK293 [72]
Gap-43 5′-UTR hnRNP-Q1 N2a cells Timed pregnant C57BL/6J mice [73]
MDM2 Adjacent to an E-box DNA motif ACBL, hnRNP family, XRCC6, XRCC5, DDX3X, EWS, Ku70-Ku80 protein dimer 93T449, HNLF, WDLPS [74]
PIM1 [75]
c-MYC Promoter A quinoxaline analog: 6,7-Difluoro-2,3-bis(4-(4-methylpiperazin-1-yl) phenyl) quinoxaline (QN-1) 4T1 cells Female BALB/c mice [76]
HOXC10 CHD7 HeLa, MDA-MB-231 [77]
CD44 Splicing cis element hnRNPF HMLE, HMLE-Twist-ER, MCF10A, HEK293 [78]