Fig. 1
From: Recent advances in targeted drug delivery systems for resistant colorectal cancer
Representation of different drug resistance mechanisms in CRC. a cancer-derived exosome. Reprinted from [24] under Creative Commons Attribution License.4.0. Copyright (2019) Frontiers. b Cancer stem cells. Reprinted from [25] with permission, Copyright (2018) John Wiley and Sons. c Circulating tumor cells. Reprinted from [26] under Creative Commons Attribution License.4.0. Copyright (2021) John Wiley and Sons. d Genomic instability. Reprinted from [27] with permission, Copyright (2018) Springer Nature. e Signaling pathways. Reprinted from [28] with permission, Copyright (2015) John Wiley and Sons