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Fig. 5 | Cancer Cell International

Fig. 5

From: KMT2B promotes the growth of renal cell carcinoma via upregulation of SNHG12 expression and promotion of CEP55 transcription

Fig. 5

The effect of SNHG12/E2F1/CEP55 on RCC cell proliferation, migration, invasion and HUVEC angiogenesis. 786-O cells were transfected with oe-SNHG12 + sh-NC, oe-SNHG12 + sh-E2F1, sh-E2F1 + oe-NC or sh-E2F1 + oe-CEP55. A The expression of E2F1 and CEP55 in 786-O cells was detected by RT-qPCR. B The proliferation ability of 786-O cells was detected by CCK-8. C Detection of 786-O cell migration by wound healing assay. D Detection of 786-O cell invasion by Transwell assay. E Analysis of the angiogenesis of HUVECs by in vitro by capillary-like tube formation assay. F Detection of the expression of MMP-2, MMP-9 and VEGF in 786-O cells by Western blot. **p < 0.01. All cell experiments were repeated three times

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Cancer Cell International

ISSN: 1475-2867

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