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Table 3 Dysregulation of DANCR in clinical samples

From: A review on the role of DANCR in the carcinogenesis

Tumor type Samples Expression (tumor vs. normal) Kaplan–Meier analysis (impact of DANCR dysregulation) Univariate/multivariate cox regression Association of dysregulation of DANCR with clinical data References
Bladder cancer 120 PTN Up Shorter OS and DFS High levels of DANCR were an independent prognostic factor for shorter OS LN metastasis status, tumor stage, histological grade [8]
106 PTN Up Higher histological grade and advanced TNM stage [9]
Breast cancer TCGA dataset
60 triple-negative (TNBC) type, 15 HER2 type, 15 Luminal A type, and 15 Luminal B type, and 10 normal breast tissues
Up in TNBC Shorter OS Bigger tumor size [27]
30 PTN Up [28]
TCGA database
46 PTN
Up Advanced tumor grades or lymph node metastasis [29]
46 PTN Up [34]
57 PTN Up Shorter OS [35]
35 TNBC tissues, 52 adjacent normal breast tissues and 25 non-TNBC breast tissues Up-regulation of TUFT1(which induces DANCR expression) in TNBC tissues Shorter OS Lower differentiation degree of TNBC cells [36]
120 BC patients, 70 BBD patients, and 105 healthy controls Up in BC patients Shorter OS DANCR was found to be an independent risk factor for BC Lymph node metastasis, ER status, HER2 status, and TNM stage [90]
Five GEO datasets: 657 breast tumors
50 TNBC and 50 non-TNBC tissues
Up in TNBC tissues OXC1/lnc-FOXCUT/lnc-DANCR axis is involved in the aggressive features of triple-negative breast tumors [93]
63 PTN Up Shorter OS TNM stages [37]
Breast cancer TCGA database: 790 BCa tissues and 104 normal tissues
12 TNBC patients and 4 normal controls
Up [38]
2192 samples from 21 studies Up [94]
Cervical cancer 65 PTN Up Shorter OS Advanced stage, larger tumors, advanced FIGO stage and lymph node metastasis [39]
82 PTN Up Shorter OS Large tumor size, advanced FIGO stage [40]
112 PTN Up Histological type, tumor staging, infiltrating muscle depth and lymphatic metastasis [41]
33 PTN Down-regulation of miR-665 (a target of DANCR)
Up-regulation of DANCR
Shorter OS Tumor size, distant metastasis, advanced TNM stage [42]
Cholangiocarcinoma 40 PTN Up Shorter OS Tumor size, TNM state and lymph node metastasis [43]
GEO database (GSE76297)
17 PTN
Up [44]
Colon cancer 35 PTN Up [21]
69 PTN Up Shorter OS [22]
Colorectal cancer 50 PTN Up TNM stage and positive lymph node metastasis [46]
80 colorectal cancer patients and 10 normal colon tissues Up Shorter OS Clinical stages [47]
40 PTN Up [48]
GEO (GSE126092) and TCGA databases
15 PTN
Up TNM stages [95]
47 PTN Up Clinical stage, nodal and metastasis classifications, and liver metastasis [49]
Colorectal cancer 104 PTN Up Shorter OS and DFS DANCR was found to be an independent poor prognostic factor for both OS and DFS TNM stage, histologic grade, and lymph node metastasis [96]
Endometrial carcinoma 27 patients and 18 normal controls Up [50]
Esophageal squamous cell carcinoma 51 PTN
Data of KMPlot tool (55 patients) and data of LinkedOmics tool (178 patients)
Down-regulation of miR-33a-5p (a target of DANCR) Shorter OS Advanced TNM stage and lymph node metastasis [52]
32 PTN Up [53]
Gastric cancer 14 DDP-sensitive GC tissues and 14 DDP-resistant GC tissues Up in DDP-resistant [30]
TCGA database
86 PTN
Up Shorter OS Tumor size, TNM stage, invasion depth, and lymph node metastasis [31]
65 PTN
55 patients and 39 healthy controls
Up Tumor size, TNM stage, lymphatic metastasis and invasion depth [32]
118 PTN Up Shorter OS [54]
Glioma 33 PTN Up Shorter OS Clinical grading and tumor size [55]
TCGA dataset
82 glioma tissues and 10 normal brain tissues
Up Tumor grading [56]
86 PTN Up Shorter OS Histological type and WHO grade [57]
47 glioma patients and 14 normal tissues Up Advanced tumor grade [59]
TCGA database
40 tumor tissues and 40 normal tissues
Up-regulation of IGF2BP2 (which increases DANCR stability) _ [61]
Hepatocellular carcinoma 62 PTN Up Shorter OS [17]
TCGA and GEPIA database
66 PTN
Up Shorter OS [18]
13 HCC patients, 10 hepatitis,
10 with cirrhosis, and 10 normal database
Up in HCC patients Shorter OS High levels of DANCR were an independent prognostic factor [19]
STARBASE and GEPIA database Up Shorter OS [20]
52 PTN
52 HCC patients, 29 patients with chronic hepatitis, 22 cirrhosis and 43 healthy controls
Up in HCC patients Microvascular and liver capsule invasion of HCC [62]
23 PTN Down [92]
Lung cancer 32 lung cancer tissues and 11 normal lung tissues Up Shorter OS   Grade [10]
GSE130779: 8 PTN
48 PTN
Up Shorter OS   TNM stage and lymph node metastasis [11]
100 patients Up   [13]
34 PTN Up   [12]
45 PTN Up Shorter OS   Advanced TNM stage, lymph node metastasis and a larger tumor size [63]
TCGA database: lung 706 adenocarcinoma and 626 lung squamous cell carcinoma samples Up   [14]
40 PTN Up   [64]
64 PTN Up Shorter OS   Larger tumor size, advanced TNM stage and lymph node metastasis [65]
128 PTN Up   [66]
40 PTN Up   [67]
Nasopharyngeal carcinoma 10 PTN
100 PTN
Up Shorter OS [70]
14 tumor tissues and 9 normal tissues
212 tumor tissue
Up Shorter OS and DFS and metastasis-free survival DANCR expression and N stage were found to be independent prognostic factors Lymph node metastasis [73]
Oral squamous cell carcinoma 86 PTN Up Shorter OS Histological grade, clinical staging and lymph node metastasis [75]
Osteosarcoma 95 PTN Up Shorter OS   advanced stage, lymph node metastasis and distant metastasis [3]
34 PTN Up   [2]
Osteosarcoma 109 PTN Up   Lymph node metastasis and distant metastasis [4]
45 PTN Up   [5]
40 PTN Up-regulation of METTL3 (DANCR could be a target of METTL3) [6]
Ovarian cancer 20 PTN Up [78]
20 PTN Up TNM staging and metastasis [79]
Pancreatic cancer 30 PTN Up [24]
50 PTN Up Shorter OS Tumor size, TNM stage, and lymph nodal metastasis [25]
206 PTN Up Shorter OS and PFS DANCR was found to be an independent poor prognostic factor for both OS and PFS Vascular invasion, advanced T stage, lymph node metastasis and advanced TNM stage [80]
68 PTN Up TNM stage, N stage, and recurrence rates [26]
Papillary thyroid cancer GEO database (GSE33630, GSE50901, and GSE66783)
76 PTN
Down DANCR was found to be an independent protective factor for TNM stage TNM stage [91]
112 PTN Up Age and micro carcinoma [97]
Prostate cancer 36 PTN Up [81]
40 PTN Up Shorter OS Grade and metastasis [82]
53 patients and 47 healthy controls Up Shorter OS PSA, Gleason score, T stage, N stage and M stage [83]
15 DTX-sensitive and 14 DTX-resistant PC tissues Up in DTX-resistant [84]
GEO database (GSE2547) Up [85]
Renal cell carcinoma 24 PTN Down [86]
Retinoblastoma 57 patients and matched health controls Up Shorter OS [87]
  1. OS: Overall survival, TNM: tumor node metastasis, TCGA: Cancer Genome Atlas, DFS: disease-free survival, HCC: hepatocellular carcinoma, PFS: progression-free survival, TNBC: Triple negative breast cancer, BC: breast cancer, BBD: benign breast disease, DTX: docetaxel, DDP: cisplatin, DFS: disease-free survival, PTN: pairs of tumor and normal samples