Table 3 Dysregulation of DANCR in clinical samples

Bladder cancer

120 PTN

Up

Shorter OS and DFS

High levels of DANCR were an independent prognostic factor for shorter OS

LN metastasis status, tumor stage, histological grade

[8]

106 PTN

Up

–

–

Higher histological grade and advanced TNM stage

[9]

Breast cancer

TCGA dataset

60 triple-negative (TNBC) type, 15 HER2 type, 15 Luminal A type, and 15 Luminal B type, and 10 normal breast tissues

Up in TNBC

Shorter OS

–

Bigger tumor size

[27]

30 PTN

Up

–

–

–

[28]

TCGA database

46 PTN

Up

–

–

Advanced tumor grades or lymph node metastasis

[29]

46 PTN

Up

–

–

–

[34]

57 PTN

Up

Shorter OS

–

–

[35]

35 TNBC tissues, 52 adjacent normal breast tissues and 25 non-TNBC breast tissues

Up-regulation of TUFT1(which induces DANCR expression) in TNBC tissues

Shorter OS

–

Lower differentiation degree of TNBC cells

[36]

120 BC patients, 70 BBD patients, and 105 healthy controls

Up in BC patients

Shorter OS

DANCR was found to be an independent risk factor for BC

Lymph node metastasis, ER status, HER2 status, and TNM stage

[90]

Five GEO datasets: 657 breast tumors

50 TNBC and 50 non-TNBC tissues

Up in TNBC tissues

–

–

OXC1/lnc-FOXCUT/lnc-DANCR axis is involved in the aggressive features of triple-negative breast tumors

[93]

63 PTN

Up

Shorter OS

–

TNM stages

[37]

Breast cancer

TCGA database: 790 BCa tissues and 104 normal tissues

12 TNBC patients and 4 normal controls

Up

–

–

–

[38]

2192 samples from 21 studies

Up

–

–

–

[94]

Cervical cancer

65 PTN

Up

Shorter OS

–

Advanced stage, larger tumors, advanced FIGO stage and lymph node metastasis

[39]

82 PTN

Up

Shorter OS

–

Large tumor size, advanced FIGO stage

[40]

112 PTN

Up

–

–

Histological type, tumor staging, infiltrating muscle depth and lymphatic metastasis

[41]

33 PTN

Down-regulation of miR-665 (a target of DANCR)

Up-regulation of DANCR

Shorter OS

–

Tumor size, distant metastasis, advanced TNM stage

[42]

Cholangiocarcinoma

40 PTN

Up

Shorter OS

–

Tumor size, TNM state and lymph node metastasis

[43]

GEO database (GSE76297)

17 PTN

Up

–

–

–

[44]

Colon cancer

35 PTN

Up

–

–

–

[21]

69 PTN

Up

Shorter OS

–

–

[22]

Colorectal cancer

50 PTN

Up

–

–

TNM stage and positive lymph node metastasis

[46]

80 colorectal cancer patients and 10 normal colon tissues

Up

Shorter OS

–

Clinical stages

[47]

40 PTN

Up

–

–

–

[48]

GEO (GSE126092) and TCGA databases

15 PTN

Up

–

–

TNM stages

[95]

47 PTN

Up

–

–

Clinical stage, nodal and metastasis classifications, and liver metastasis

[49]

Colorectal cancer

104 PTN

Up

Shorter OS and DFS

DANCR was found to be an independent poor prognostic factor for both OS and DFS

TNM stage, histologic grade, and lymph node metastasis

[96]

Endometrial carcinoma

27 patients and 18 normal controls

Up

–

–

–

[50]

Esophageal squamous cell carcinoma

51 PTN

Data of KMPlot tool (55 patients) and data of LinkedOmics tool (178 patients)

Down-regulation of miR-33a-5p (a target of DANCR)

Shorter OS

–

Advanced TNM stage and lymph node metastasis

[52]

32 PTN

Up

–

–

–

[53]

Gastric cancer

14 DDP-sensitive GC tissues and 14 DDP-resistant GC tissues

Up in DDP-resistant

–

–

–

[30]

TCGA database

86 PTN

Up

Shorter OS

–

Tumor size, TNM stage, invasion depth, and lymph node metastasis

[31]

65 PTN

55 patients and 39 healthy controls

Up

–

–

Tumor size, TNM stage, lymphatic metastasis and invasion depth

[32]

118 PTN

Up

Shorter OS

–

–

[54]

Glioma

33 PTN

Up

Shorter OS

–

Clinical grading and tumor size

[55]

TCGA dataset

82 glioma tissues and 10 normal brain tissues

Up

–

–

Tumor grading

[56]

86 PTN

Up

Shorter OS

–

Histological type and WHO grade

[57]

47 glioma patients and 14 normal tissues

Up

–

–

Advanced tumor grade

[59]

TCGA database

40 tumor tissues and 40 normal tissues

Up-regulation of IGF2BP2 (which increases DANCR stability)

–

–

_

[61]

Hepatocellular carcinoma

62 PTN

Up

Shorter OS

–

–

[17]

TCGA and GEPIA database

66 PTN

Up

Shorter OS

–

–

[18]

13 HCC patients, 10 hepatitis,

10 with cirrhosis, and 10 normal database

Up in HCC patients

Shorter OS

High levels of DANCR were an independent prognostic factor

–

[19]

STARBASE and GEPIA database

Up

Shorter OS

–

–

[20]

52 PTN

52 HCC patients, 29 patients with chronic hepatitis, 22 cirrhosis and 43 healthy controls

Up in HCC patients

–

–

Microvascular and liver capsule invasion of HCC

[62]

23 PTN

Down

–

–

–

[92]

Lung cancer

32 lung cancer tissues and 11 normal lung tissues

Up

Shorter OS

Grade

[10]

GSE130779: 8 PTN

48 PTN

Up

Shorter OS

TNM stage and lymph node metastasis

[11]

100 patients

Up

–

–

[13]

34 PTN

Up

–

–

[12]

45 PTN

Up

Shorter OS

Advanced TNM stage, lymph node metastasis and a larger tumor size

[63]

TCGA database: lung 706 adenocarcinoma and 626 lung squamous cell carcinoma samples

Up

–

–

[14]

40 PTN

Up

–

–

[64]

64 PTN

Up

Shorter OS

Larger tumor size, advanced TNM stage and lymph node metastasis

[65]

128 PTN

Up

–

–

[66]

40 PTN

Up

–

–

[67]

Nasopharyngeal carcinoma

10 PTN

100 PTN

Up

Shorter OS

–

–

[70]

14 tumor tissues and 9 normal tissues

212 tumor tissue

Up

Shorter OS and DFS and metastasis-free survival

DANCR expression and N stage were found to be independent prognostic factors

Lymph node metastasis

[73]

Oral squamous cell carcinoma

86 PTN

Up

Shorter OS

–

Histological grade, clinical staging and lymph node metastasis

[75]

Osteosarcoma

95 PTN

Up

Shorter OS

advanced stage, lymph node metastasis and distant metastasis

[3]

34 PTN

Up

–

–

[2]

Osteosarcoma

109 PTN

Up

–

Lymph node metastasis and distant metastasis

[4]

45 PTN

Up

–

–

[5]

40 PTN

Up-regulation of METTL3 (DANCR could be a target of METTL3)

–

–

–

[6]

Ovarian cancer

20 PTN

Up

–

–

–

[78]

20 PTN

Up

–

–

TNM staging and metastasis

[79]

Pancreatic cancer

30 PTN

Up

–

–

–

[24]

50 PTN

Up

Shorter OS

–

Tumor size, TNM stage, and lymph nodal metastasis

[25]

206 PTN

Up

Shorter OS and PFS

DANCR was found to be an independent poor prognostic factor for both OS and PFS

Vascular invasion, advanced T stage, lymph node metastasis and advanced TNM stage

[80]

68 PTN

Up

–

–

TNM stage, N stage, and recurrence rates

[26]

Papillary thyroid cancer

GEO database (GSE33630, GSE50901, and GSE66783)

76 PTN

Down

–

DANCR was found to be an independent protective factor for TNM stage

TNM stage

[91]

112 PTN

Up

–

–

Age and micro carcinoma

[97]

Prostate cancer

36 PTN

Up

–

–

–

[81]

40 PTN

Up

Shorter OS

–

Grade and metastasis

[82]

53 patients and 47 healthy controls

Up

Shorter OS

–

PSA, Gleason score, T stage, N stage and M stage

[83]

15 DTX-sensitive and 14 DTX-resistant PC tissues

Up in DTX-resistant

–

–

–

[84]

GEO database (GSE2547)

Up

–

–

–

[85]

Renal cell carcinoma

24 PTN

Down

–

–

–

[86]

Retinoblastoma

57 patients and matched health controls

Up

Shorter OS

–

–

[87]