Fig. 4 

Construction of m6Sig score and explore the relevance of clinical features. A Alluvial diagram of m6A clusters in groups with different m6A-gene clusters, m6Ascores and survival status. B Correlations between m6Ascore and the well-established biological gene signatures using Spearman analysis. The negative correlation is marked with blue and positive correlation with red. C Kaplan–Meier curves for high and low m6Ascore patient groups. Log-rank test, P < 0.001. D Univariate Cox regression results of overall survival. The length of the horizontal line represents the 95% confidence interval for each group. The vertical dotted line represents the hazard ratio (HR) of all patients. E Multivariate Cox regression results of overall survival. The length of the horizontal line represents the 95% confidence interval for each group. The vertical dotted line represents the hazard ratio (HR) of all patients. F The difference of m6Ascore among distinct m6A gene clusters, P < 0.001. G The difference of m6Ascore among distinct m6A gene clusters, P < 0.001. Clinical significance of the m6Ascore. H Age. I Grade. J Tumor