Fig. 7

The role of in prognostic prediction, TIME, and biological processes of PAAD. A TNFRSF21 are upregulated in PAAD samples based on TCGA dataset. B TNFRSF21 are upregulated in PAAD cell lines. A lower TNFRSF21 expression level was significantly correlated with longer overall survival time C and disease-free survival time (D). E Correlation analysis of TNFRSF21 expression level with infiltrating B, CD4 + T, CD8 + T, dendritic cells, macrophage and neutrophil cells using TIMER. F Comparison of tumor infiltration levels among PAAD samples with different somatic copy number alterations in TNFRSF21. G Top 4 pathways enriched in the KEGG analysis in PAAD. H Top 5 pathways enriched in the GO analysis in PAAD. The IC50 differences of (I) bleomycin, (J) rapamycin, (K) sunitinib and (L) Vinblastine predicted by the pRRophetic algorithm between high-/low- TNFRSF21 expression subgroups