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Fig. 1 | Cancer Cell International

Fig. 1

From: Circular RNA EPB41 expression predicts unfavorable prognoses in NSCLC by regulating miR-486-3p/eIF5A axis-mediated stemness

Fig. 1

The expression of circ-EPB41 predicted an unfavorable prognosis in NSCLC patients. A Clustered heat map for tissue-specific circRNAs from three normal and cancerous human tissues. B We validated the differential expression of six circRNAs in 10 paired NSCLC tissues using RT-qPCR. C The genomic loci of the EPB41 gene and circ-EPB41. D The expression and subcellular localization of circ-EPB41 in NSCLC was analyzed by in situ hybridization on a NSCLC tissue. E RT-qPCR detection showed the expression of circ-EPB41 in 90 paired NSCLC tissues. Data are presented as means ± SD; ***P < 0.001 vs normal group. F RT-qPCR detection showed the expression of circ-EPB4 in A549, PC9, H1650, H1975 and normal lung epithelial cells (BEAS-2B). Data are presented as means ± SD; ***P < 0.001 vs normal group. G The overall survival probability of patients with higher and lower circ-EPB41 were determined by Kaplan–Meier survival analysis

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Cancer Cell International

ISSN: 1475-2867

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