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Table 3 Post-translational modification (PTM) of NFATc4

From: Recent knowledge of NFATc4 in oncogenesis and cancer prognosis

Enzyme PTM Studied sites Verification References
Calcineurin Dephosphorylation multisites 3 [2]
p38 MAP kinase Phosphorylation Ser168, 170 3, 4 [35, 39]
mTOR Phosphorylation Ser168, 170 2, 3 [35]
MAPK7 (ERK5) Phosphorylation Ser168, 170 2, 3 [35]
IRAK-1 Phosphorylation Ser168, 170 3 [40]
JNK1/2 Phosphorylation Ser213, 217 2, 3, 4 [41]
CDK3 Phosphorylation Ser259 2, 3, 4 [19]
PKA Phosphorylation Ser272, 289 2, 3, 4 [42]
RSK2 Phosphorylation Ser289, 344, 676 1, 2, 3, 4 [43, 44]
PARP-1 ADP-ribosylation Glu418 1, 2, 3, 4 [36]
- Ubiquitination - 3 [37]
SIRT6 Deacetylation - 3 [38]
  1. 1: Mass spectrometry; 2: Autoradiography; 3: Immunoblot; 4: Site mutation