Recent knowledge of NFATc4 in oncogenesis and cancer prognosis

Table 5 Downstream genes of NFATc4 in cancer

Gene	NFATc4 activity	Related cancer	Regulation	References
COX-2	Promotes	Lung cancer	Cell apoptosis	[55, 56]
TNFα	Promotes	-	Cell apoptosis	[68]
pS2	Promotes	Breast cancer	Cell growth	[48]
cathepsin D	Promotes	Breast cancer	Cell growth	[48]
LCN2	Represses	Breast cancer	Cell migration	[13]
CXCR4	Promotes	Ovarian cancer	Tumor spheroid formation	[16]
SOX9	Promotes	Pancreatic cancer	Cancer initiation	[20]
KROX20	Activates	Schwannoma	Cell growth	[23, 53]
P0	Promotes	Schwannoma	Cell growth	[23, 53]

ISSN: 1475-2867