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Figure. 2. | Cancer Cell International

Figure. 2.

From: Identification of icaritin derivative IC2 as an SCD-1 inhibitor with anti-breast cancer properties through induction of cell apoptosis

Figure. 2.

ICT derivatives mediate the inhibition of SCD1 activity and prediction of the binding mode by CADD. A The 2D structures of ICT, IC1, IC2 and IC3. B Cross-sections of the hSCD1 surface area (light red) docked with ICT, IC1, IC2 and IC3 (yellow sticks). C The interaction and binding energies of hSCD1 with ICT, IC1, IC2 and IC3. D The nonbinding interactions of hSCD1 with IC2. IC2 is depicted with yellow sticks, and interacting residues are depicted with cyan sticks. The hSCD1-IC-2 interactions are shown on a 2D diagram

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