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Fig. 7 | Cancer Cell International

Fig. 7

From: Identification of icaritin derivative IC2 as an SCD-1 inhibitor with anti-breast cancer properties through induction of cell apoptosis

Fig. 7

IC2-induced antiproliferation effect depends on the inhibition of SCD1 in MCF-7 cells. A IC2 treatment inhibited both total (SCD1 antibody) and exogenous (Flag antibody) SCD1 expression in LV-SCD1 cells. B Quantification of the protein expression levels of SCD1 in A. C SCD1 overexpression alleviated IC2-induced cell growth inhibition. D OA rescued the reduced cell viability induced by IC2. E PA did not rescue the IC2-induced reduced cell viability. F Observation under the microscope at ×50 magnification found that overexpression of SCD1 rescued the IC2-induced reduced cell viability. Data are presented as the mean ± SEM of three independent experiments (n = 3). *P < 0.05, **P < 0.01 and ***P < 0.001 vs. control

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