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Fig. 7 | Cancer Cell International

Fig. 7

From: Metallothionein 2A (MT2A) controls cell proliferation and liver metastasis by controlling the MST1/LATS2/YAP1 signaling pathway in colorectal cancer

Fig. 7

Schematic of MT2A overexpression mediated inhibition of cell growth and liver metastasis in CRC cells. Normally, Hippo pathway is inactive, YAP is unphosphorylated and localized in the nucleus to bind with TEAD and activation of gene transcription, but when MT2A overexpressed, MST1 phosphorylates LATS2, and then phosphorylates YAP1. Phosphorylated YAP1 is exported from nucleus and inhibits gene transcription

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Cancer Cell International

ISSN: 1475-2867

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